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Genome-Wide Association Study for Adiponectin Levels in Filipino Women Identifies CDH13 and a Novel Uncommon Haplotype at KNG1-ADIPOQ

Citation

Wu, Ying; Li, Yun; Lange, Ethan M.; Croteau-Chonka, Damien C.; Kuzawa, Christopher W.; McDade, Thomas W.; Qin, Li; Curocichin, Ghenadie; Borja, Judith B.; & Lange, Leslie A., et al. (2010). Genome-Wide Association Study for Adiponectin Levels in Filipino Women Identifies CDH13 and a Novel Uncommon Haplotype at KNG1-ADIPOQ. Human Molecular Genetics, 19(24), 4955-4964. PMCID: PMC2989895

Abstract

Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1,776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Our strongest signal for adiponectin mapped to the gene CDH13 (rs3865188, P = 7.2 × 10(-16)), which encodes a receptor for high-molecular-weight forms of adiponectin. Strong association was also detected near the ADIPOQ gene (rs864265, P = 3.8 × 10(-9)) and at a novel signal 100 kb upstream near KNG1 (rs11924390, P = 7.6 × 10(-7)). All three signals were also observed in 1,774 young adult CLHNS offspring and in combined analysis including all 3,550 mothers and offspring samples (all P < 1.6 × 10(-9)). An uncommon haplotype of rs11924390 and rs864265 (haplotype frequency = 0.050) was strongly associated with lower adiponectin compared with the most common C-G haplotype in both CLHNS mothers (P = 1.8 × 10(-25)) and offspring (P = 8.7 × 10(-32)). Comprehensive imputation of 2,653 SNPs in a 2 Mb region using as reference combined CHB, JPT and CEU haplotypes from the 1000 Genomes Project revealed no variants that perfectly tagged this haplotype. Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1-ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos.

URL

http://dx.doi.org/10.1093/hmg/ddq423

Reference Type

Journal Article

Year Published

2010

Journal Title

Human Molecular Genetics

Author(s)

Wu, Ying
Li, Yun
Lange, Ethan M.
Croteau-Chonka, Damien C.
Kuzawa, Christopher W.
McDade, Thomas W.
Qin, Li
Curocichin, Ghenadie
Borja, Judith B.
Lange, Leslie A.
Adair, Linda S.
Mohlke, Karen L.

PMCID

PMC2989895