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Replication of LIN28B SNP Association with Age of Menarche in Young Filipino Women


Croteau-Chonka, Damien C.; Lange, Leslie A.; Lee, Nanette R.; Adair, Linda S.; & Mohlke, Karen L. (2013). Replication of LIN28B SNP Association with Age of Menarche in Young Filipino Women. Pediatric Obesity, 8(5), e50-3. PMCID: PMC3772980


Background: Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease. Objectives: We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Methods: We tested rs7759938 for additive association with age of menarche and also tested whether childhood adiposity, as measured by body mass index (BMI) at age 8, mediated this relationship. Results: We observed nominal association of rs7759938 with age of menarche (β = −0.118 years, 95% confidence interval = (−0.216, −0.020), P = 0.019) with an effect direction consistent with the previous report. We also observed suggestive evidence that the effect of the SNP on age of menarche was independent of childhood BMI. Conclusions: These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.


Reference Type

Journal Article

Year Published


Journal Title

Pediatric Obesity


Croteau-Chonka, Damien C.
Lange, Leslie A.
Lee, Nanette R.
Adair, Linda S.
Mohlke, Karen L.