Citation

Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; Justice, Anne E.; Pers, Tune H.; Day, Felix R.; Powell, Corey; Vedantam, Sailaja; Buchkovich, Martin L.; & Yang, Jian, et al. (2015). Genetic Studies of Body Mass Index Yield New Insights for Obesity Biology. Nature, 518(7538), 197-206.

Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 [times] 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for [sim]2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

URL

http://dx.doi.org/10.1038/nature14177

Reference Type

Journal Article

Year Published

2015

Journal Title

Nature

Author(s)

Locke, Adam E.
Kahali, Bratati
Berndt, Sonja I.
Justice, Anne E.
Pers, Tune H.
Day, Felix R.
Powell, Corey
Vedantam, Sailaja
Buchkovich, Martin L.
Yang, Jian
Croteau-Chonka, Damien C.
Esko, Tonu
Fall, Tove
Ferreira, Teresa
Gustafsson, Stefan
Kutalik, Zoltan
Luan, Jian'an
Magi, Reedik
Randall, Joshua C.
Winkler, Thomas W.
Wood, Andrew R.
Workalemahu, Tsegaselassie
Faul, Jessica D.
Smith, Jennifer A.
Hua Zhao, Jing
Zhao, Wei
Chen, Jin
Fehrmann, Rudolf
Hedman, Asa K.
Karjalainen, Juha
Schmidt, Ellen M.
Absher, Devin
Amin, Najaf
Anderson, Denise
Beekman, Marian
Bolton, Jennifer L.
Bragg-Gresham, Jennifer L.
Buyske, Steven
Demirkan, Ayse
Deng, Guohong
Ehret, Georg B.
Feenstra, Bjarke
Feitosa, Mary F.
Fischer, Krista
Goel, Anuj
Gong, Jian
Jackson, Anne U.
Kanoni, Stavroula
Kleber, Marcus E.
Kristiansson, Kati
Lim, Unhee
Lotay, Vaneet
Mangino, Massimo
Mateo Leach, Irene
Medina-Gomez, Carolina
Medland, Sarah E.
Nalls, Michael A.
Palmer, Cameron D.
Pasko, Dorota
Pechlivanis, Sonali
Peters, Marjolein J.
Prokopenko, Inga
Shungin, Dmitry
Stancakova, Alena
Strawbridge, Rona J.
Ju Sung, Yun
Tanaka, Toshiko
Teumer, Alexander
Trompet, Stella
van der Laan, Sander W.
van Setten, Jessica
Van Vliet-Ostaptchouk, Jana V.
Wang, Zhaoming
Yengo, Loic
Zhang, Weihua
Isaacs, Aaron
Albrecht, Eva
Arnlov, Johan
Arscott, Gillian M.
Attwood, Antony P.
Bandinelli, Stefania
Barrett, Amy
Bas, Isabelita N.
Bellis, Claire
Bennett, Amanda J.
Berne, Christian
Blagieva, Roza
Bluher, Matthias
Bohringer, Stefan
Bonnycastle, Lori L.
Bottcher, Yvonne
Boyd, Heather A.
Bruinenberg, Marcel
Caspersen, Ida H.
Ida Chen, Yii-Der
Clarke, Robert
Warwick Daw, E.
de Craen, Anton J.M.
Delgado, Graciela
Dimitriou, Maria
Doney, Alex S.F.
Eklund, Niina
Estrada, Karol
Eury, Elodie
Folkersen, Lasse
Fraser, Ross M.
Garcia, Melissa E.
Geller, Frank
Giedraitis, Vilmantas
Gigante, Bruna
Go, Alan S.
Golay, Alain
Goodall, Alison H.
Gordon, Scott D.
Gorski, Mathias
Grabe, Hans-Jorgen
Grallert, Harald
Grammer, Tanja B.
Graszler, Jurgen
Gronberg, Henrik
Groves, Christopher J.
Gusto, Gaelle
Haessler, Jeffrey
Hall, Per
Haller, Toomas
Hallmans, Goran
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Hassinen, Maija
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Helmer, Quinta
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Koskenvuo, Markku
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Laitinen, Jaana
Lamina, Claudia
Leander, Karin
Lee, Nanette R.
Lichtner, Peter
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Lindstrom, Jaana
Sin Lo, Ken
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Lorbeer, Roberto
Lu, Yingchang
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Mahajan, Anubha
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Muller-Nurasyid, Martina
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Shi, Jianxin
Vernon Smith, Albert
Smolonska, Joanna
Stanton, Alice V.
Steinthorsdottir, Valgerdur
Stirrups, Kathleen
Stringham, Heather M.
Sundstrom, Johan
Swertz, Morris A.
Swift, Amy J.
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Tayo, Bamidele O.
Thorand, Barbara
Thorleifsson, Gudmar
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Vandenput, Liesbeth
Verhulst, Frank C.
Vermeulen, Sita H.
Verweij, Niek
Vonk, Judith M.
Waite, Lindsay L.
Warren, Helen R.
Waterworth, Dawn
Weedon, Michael N.
Wilkens, Lynne R.
Willenborg, Christina
Wilsgaard, Tom
Wojczynski, Mary K.
Wong, Andrew
Wright, Alan F.
Zhang, Qunyuan
The LifeLines Cohort Study
Brennan, Eoin P.
Choi, Murim
Dastani, Zari
Drong, Alexander W.
Eriksson, Per
Franco-Cereceda, Anders
Gadin, Jesper R.
Gharavi, Ali G.
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Handsaker, Robert E.
Huang, Jinyan
Karpe, Fredrik
Kathiresan, Sekar
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Kiryluk, Krzysztof
Kubo, Michiaki
Lee, Jong-Young
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Perry, John R.B.
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Takahashi, Atsushi
Tanaka, Toshihiro
van't Hooft, Ferdinand M.
Vinkhuyzen, Anna A.E.
Westra, Harm-Jan
Zheng, Wei
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The ADIPOGen Consortium
The Agen-B.M.I. Working Group
The CARDIOGRAMplusC.D. Consortium
The CKDGen Consortium
The GLGC
The ICBP
The Magic Investigators
The Mu Ther Consortium
The MIGen Consortium
The Page Consortium
The ReproGen Consortium
The Genie Consortium
The International Endogene Consortium
Heath, Andrew C.
Arveiler, Dominique
Bakker, Stephan J.L.
Beilby, John
Bergman, Richard N.
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