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Meta-Analysis of Genome-Wide Association Studies in East Asian-Ancestry Populations Identifies Four New Loci for Body Mass Index

Citation

Wen, Wanqing; Zheng, Wei; Okada, Yukinori; Takeuchi, Fumihiko; Tabara, Yasuharu; Hwang, Joo-Yeon; Dorajoo, Rajkumar; Li, Huaixing; Tsai, Fuu-Jen; & Yang, Xiaobo, et al. (2014). Meta-Analysis of Genome-Wide Association Studies in East Asian-Ancestry Populations Identifies Four New Loci for Body Mass Index. Human Molecular Genetics, 23(20), 5492-5504.

Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10−13), ALDH2/MYL2 (rs671, P = 3.40 × 10−11; rs12229654, P = 4.56 × 10−9), ITIH4 (rs2535633, P = 1.77 × 10−10) and NT5C2 (rs11191580, P = 3.83 × 10−8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10−8) and an additional 14 at P < 1.0 × 10−3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

URL

http://dx.doi.org/10.1093/hmg/ddu248

Reference Type

Journal Article

Year Published

2014

Journal Title

Human Molecular Genetics

Author(s)

Wen, Wanqing
Zheng, Wei
Okada, Yukinori
Takeuchi, Fumihiko
Tabara, Yasuharu
Hwang, Joo-Yeon
Dorajoo, Rajkumar
Li, Huaixing
Tsai, Fuu-Jen
Yang, Xiaobo
He, Jiang
Wu, Ying
He, Meian
Zhang, Yi
Liang, Jun
Guo, Xiuqing
Sheu, Wayne Huey-Herng
Delahanty, Ryan
Guo, Xingyi
Kubo, Michiaki
Yamamoto, Ken
Ohkubo, Takayoshi
Go, Min Jin
Liu, Jian Jun
Gan, Wei
Chen, Ching-Chu
Gao, Yong
Li, Shengxu
Lee, Nanette R.
Wu, Chen
Zhou, Xueya
Song, Huaidong
Yao, Jie
Lee, I-Te
Long, Jirong
Tsunoda, Tatsuhiko
Akiyama, Koichi
Takashima, Naoyuki
Cho, Yoon Shin
Ong, Rick T.H.
Lu, Ling
Chen, Chien-Hsiun
Tan, Aihua
Rice, Treva K.
Adair, Linda S.
Gui, Lixuan
Allison, Matthew
Lee, Wen-Jane
Cai, Qiuyin
Isomura, Minoru
Umemura, Satoshi
Kim, Young Jin
Seielstad, Mark
Hixson, James
Xiang, Yong-Bing
Isono, Masato
Kim, Bong-Jo
Sim, Xueling
Lu, Wei
Nabika, Toru
Lee, Juyoung
Lim, Wei-Yen
Gao, Yu-Tang
Takayanagi, Ryoichi
Kang, Dae-Hee
Wong, Tien Yin
Hsiung, Chao Agnes
Wu, I-Chien
Juang, Jyh-Ming Jimmy
Shi, Jiajun
Choi, Bo Youl
Aung, Tin
Hu, Frank
Kim, Mi Kyung
Lim, Wei Yen
Wang, Tzung-Dao
Shin, Min-Ho
Lee, Jeannette
Ji, Bu-Tian
Lee, Young-Hoon
Young, Terri L.
Shin, Dong Hoon
Chun, Byung-Yeol
Cho, Myeong-Chan
Han, Bok-Ghee
Hwu, Chii-Min
Assimes, Themistocles L.
Absher, Devin
Yan, Xiaofei
Kim, Eric
Kuo, Jane Z.
Kwon, Soonil
Taylor, Kent D.
Chen, Yii-Der I.
Rotter, Jerome I.
Qi, Lu
Zhu, Dingliang
Wu, Tangchun
Mohlke, Karen L.
Gu, Dongfeng
Mo, Zengnan
Wu, Jer-Yuarn
Lin, Xu
Miki, Tetsuro
Tai, E. Shyong
Lee, Jong-Young
Kato, Norihiro
Shu, Xiao-Ou
Tanaka, Toshihiro